The aim of the present work was to investigate the possibility of enhancing the dissolution rate of ketoprofen (KP) through inclusion into SBA-15 mesoporous silica nanoparticles. Two different KP concentrations were loaded into SBA-15. The loading capacity was examined via solvent extraction method, differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXRD). Characterization of the loaded mesoporous silica nanoparticles was done by high resolution transmission electron microscopy (HRTEM), small angle X-ray diffraction (SAXRD) and nitrogen adsorption/desorption isotherms. The characterization results revealed successful inclusion of KP into SBA-15 without affecting the mesoporous structure; also it showed that all KP loaded was confined into the mesopores without any trace for surface adsorbed molecules. Dissolution studies were carried out at pH 1.2 and 6.8. The results showed that KP release from SBA-15 was highly improved independent on the pH of the release medium. This study is a promising issue for providing a more facile way to improve the dissolution rate of poorly water-soluble drugs through incorporation into mesoporous silica nanoparticles.
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